Vol. 4 No. 3 September 1999

Volume 4 (1999) pp 219-302
List of Abstracts
Abstracts List PREFACE - p325

PURINE NUCLEOSIDE PHOSPHORYLASES: PROPERTIES, FUNCTIONS, AND CHEMOTHERAPEUTIC APPLICATIONS
David Shugar - p327

CAPILLARY ELECTROPHORESIS FOR DIAGNOSING PURINE INHERITED DISORDERS - TWO COMPLEMENTARY APPROACHES
T. Adam, D. Friedecký, L. D. Fairbanks, P. Barták And J. Ševčík- p329

DEPLETION OF GUANINE NUCLEOTIDES IN HUMAN NEUROBLASTOMA CELL LINES
A. M. Agliano, P. Gazzaniga, E. Messina, V. Micheli, G. Spoto And A. Giacomello - p330

DELETION AND POINT MUTANTS OF RECOMBINANT BOVINE 5'-NUCLEOTIDASE
S. Allegrini, A. Faedda, R. Pesi, F. Luculli, S. Eriksson And M.G. Tozzi - p331

STUDIES ON PYRIMIDINE NUCLEOTIDASES / PHOSPHOTRANSFERASES FROM HUMAN ERYTHROCYTE
A. Amici, M. Emanuelli, V. Naponelli, N. Raffaelli, S. Ruggieri, F. Saccucci And G. Magni - p333

ROLE OF ATP, DINUCLEOSIDE POLYPHOSPHATES AND ADENOSINE RECEPTORS IN RENAL FUNCTION
S. Angielski - p334

METABOLIC PROPERTIES OF PURINE AND PYRIMIDINE NUCLEOSIDE ANALOGUES, ACTIVE AGAINST HIV
J. Balzarini - p335

ENANTIOSPECIFICITY OF HUMAN DEOXYCYTIDINE KINASE (dCK) AND THYMIDINE KINASES (TK1 AND TK2) TOWARDS 3'-BRANCHED HOMOLOGUES OF 2'-DEOXYNUCLEOSIDES
M. Banrowski, K. Krawiec, N.G. Johansson, D. Shugar And B. Kierdaszuk - p336

NOVEL ADENOSINE DEAMINASE INHIBITORS AND THEIR CYTOPROTECTIVE EFFECTS
J. Barankiewicz - p337

AMINO ACID 106 IN HUMAN CYTOSOLIC THYMIDINE KINASE IS A VALINE, AND IS IMPORTANT FOR THE OLIGOMERISATION AND ENZYMATIC PROPERTIES
D. Berenstein, J. F. Christensen, H. Frederiksen, T. Kristensen And B. Munch-Petersen - p338

COLLATERAL SENSITIVITY TO GEMCITABINE OF P-GP AND MRP OVER--EXPRESSING HUMAN NON-SMALL CELL LUNG CANCER (NSCLC) CELL LINES: A POSSIBLE ROLE OF CORTICOSTEROIDS
A. M. Bergman, H. M. Pinedo, W.J. P. Loves, G. Veerman And G. J.Peters - p339

CYTOTOXICTY OF CYCLOPENTENYL CYTOSINE TOWARDS NEUROBLASTOMA CELL LINE CELLS
J. Bierau, A. H. Van Gennip And A. B. P. Van Kuilenburg - p340

METABOLISM AND CYTOTOXIC EFFECTS OF 2-CHLOROADENINE, THE MAJOR CATABOLITE OF 2-CHLORO-2'-DEOXYADENOSINE
F. Bontemps, A. Delacauw, S. Cardoen, E. Van Den Neste And G. Van Den Berghe - p341

HUMAN RED BLOOD CELL THIOPURINE METHYL TRANSFERASE : HPLC ASSAY FOR PHENOTYPE DETERMINATION
R. Boulieu, I. Gallant, M. Sauviat And T. Dervieux - p342

HPLC-DETERMINATION OF THIOPURINE METHYLTRANSFERASE (TPMT)-ACTIVITY
C. Brouwer, J. J. Keizer-Garritsen, R. A. De Abreu, J. P.M. Bökkerink, P. G. J. H. Ter Riet And J. M. F. Trijbels - p343

6-ARYLOXY-2-CHLORO- AND 6-ALKOXYARYL-2-CHLOROPURINES ARE POTENT INHIBITORS OF E. COLI PURINE NUCLEOSIDE PHOSPHORYLASE (PNP)
A. Bzowska, L. Magnowska And Z.Kazimierczuk - p344

AN UNEXPECTED EFFECT OF 2-CHLORO-2'DEOXYADENOSINE ON DNA SYNTHESIS IN EHEB CELLS
S. Cardoen, F. Bontemps, E. Van Den Neste And G. Van Den Berghe - p346

OXIDATIVE STRESS AND ISCHEMIC DAMAGE IN PATIENTS UNDERGOING CORONARY ARTERY BY-PASS SURGERY
F. Carlucci, B. Biagioli, M. Maccherini, G. Sani, G. Lisi, E. Marinello And A. Tabucchi - p347

ANTIBODIES AND NUCLEOTIDE ANALOGUES: THEIR EFFECT ON THE ALLOSTERIC RESPONSE IN THE AMMALIAN CARBAMOYL PHOSPHATE SYNTHETASE II (CPS II), THE KEY REACTION IN PYRIMIDINE BIOSYNTHESIS
E. A. Carrey And L. Zhu - p349

WHEN [2-3H]INOSITOL IS ADDED TO INTRA-ABDOMINAL EHRLICH TUMOUR CELL GROWTHS IN MICE, THE ATP AND GTP OF THE HARVESTED CELLS ARE STABLY LABELLED WITH 3H IN BOTH RIBOSE AND BASE
S. Christensen, H. Klenow And K. Overgaard-Hansen - p350

ECTO-NUCLEOTIDASE ACTIVITY OF CULTURED RAT SUPERIOR CERVICAL GANGLIA
G. P. Connolly And J. A. Duley - p351

METHYL ORANGE: A SELECTIVE ANTAGONIST FOR PYRIMIDINOCEPTORS
G. P. Connolly - p352

THE USE OF ADENOSINE RELEASING AGENTS IN THE CLINIC: METHOTREXATE AND SULFASALASINE
B. Cronstein - p353

DEVELOPMENT OF HAEMATOPOIETIC TOXICITY DURING THIOPURINE MEDICATION, RELATION WITH (THIO)PURINE ENZYME DEFICIENCY
R. A. De Abreu, L. M. Lambooy, J. J. Keizer-Garritsen, J. N. Stolk And A. M. Th. Boerbooms - p354

THE ROLE OF ADENOSINE IN PRECONDITIONING
J. W. De Jong, R. De Jonge And S. Bradamante - p355

PURINE AND PYRIMIDINE PHOSPHORIBOSYLTRANSFERASE ACTIVITIES IN HUMAN LYMPHOCYTES
F. Di Marcello, V. Micheli, B. Burroni, G. Jacomelli, L. Notarantonio And G. Pompucci - p356

URINARY EXCRETION OF SOME METHYLATED PURINE BASES IN HEALTY SUBJECTS
M. C. Di Pietro, G. Liso, M. D'Ercole, B. Porcelli, R. Leoncini, E. Mańnello And D. Vannoni - p358

RAISED PLASMA ADENOSINE IN CHRONIC FATIGUE SYNDROME
J. Duley, E. Shobowale-Bakre, P. Garrick And D. Pratt - p359

EFFECT OF ORAL INOSINE ON PURINELEVELS IN PLASMA AND URINE AND ERYTHROCYTE NUCLEOTIDES IN HUMANS
J. A. Duley And L. Mcnaughton - p361

PURINE NUCLEOSIDES METABOLISM IN BLOOD FRACTIONS FROM PATIENTS WITH GRAVES' OR HASHIMOTO DISEASES
K. Fabianowska - Majewska, M. Karbownik, K. Zasada, A. Lewiński And D. Wyczechowska - p363

INDUCIBLE OVEREXPRESSION OF CYTOSOLIC 5'NUCLEOTIDASES IN MAMMALIAN CELLS
C. Gazziola, M. Moras, P. Ferraro, C. Rampazzo, L. Gallinaro, P. Reichard Nd V. Bianchi - p364

DECREASED IN VIVO TOXICITY AND ENHANCED CYTOTOXICITY OF FdUMP[10]
W. H. Gmeiner, J. Liu And J. Talmadge - p366

IS DECREASED RENAL URIC ACID EXCRETION IN FAMILIAL HYPERURICEMIA LINKED TO 17q21?
J. Grässler, B. Parpart, E. Kuhlisch, F. Spitzenberger, S. Kopprasch And H. E. Schröder - p367

REGULATION OF CARBAMOYL PHOSPHATE SYNTHETASE II (CAD) BY MAP KINASE; A NEW LINK TO PYRIMIDINE NUCLEOTIDE SYNTHESIS?
L. M. Graves, H. I. Guy, P. Kozlowski, E. N. Dahlstrand, E. Lazarowski, M. Collins, H. S. Earp And D. R. Evans - p369

THE EFFECT OF OXIDATIVE DAMAGE ON ATP LEVEL IN HEAT STRESSED ENDOTHELIAL CELLS
C. C. Gray, R.T. Smolenski, M.Amrani, G.Taylor And M. H. Yacoub - p370

EXCLUSION OF FOUR CANDIDATE KIDNEY DISEASE LOCI BY LINKAGE ANALYSIS IN FAMILIAL Juvenile Hyperuricaemic Nephropathy (Fjhn)
M. Greener, A. M. Marinaki, M. M. Town, F. Moro, H.A. Simmonds, J. S. Cameron, J. A. Duley And C. Mathew - p371

SPECIFIC AND NONSPECIFIC ENZYMES INVOLVED IN THE CATABOLISM OF MINOR MONO- AND DINUCLEOSIDE POLYPHOSPHATES
A. Guranowski - p372

6-MERCAPTOPURINE METABOLISM AND TPMT ACTIVITY IN CHILDREN WITH ALL UNDER MAINTENANCE THERAPY
S .Gutsche, T. Kröplin, P. Bucsky And H. Iven - p373

ALLOGENEIC BONE MARROW TRANSPLANTATION CORRECTS THE IMMUNODEFICIENCY IN PNP DEFICIENCY BUT DOES NOT REVERSE THE NEUROLOGICAL ABNORMALITIES
R. J. Hallett, B. Gaspar, J. A. Duley, L. D. Fairbanks And H. A. Simmonds - p374

ABNORMAL INTRACELLULAR SIGNALLING IN SKIN FIBROBLASTS FROM LNS PATIENTS AND HGPRT-DEFICIENT NEUROBLASTOMA
S. P. Hussain, N. Alexander, J. A. Duley And G. P. Connolly - p375

PURINE AND PYRIMIDINE LEVELS IN CULTURED SKIN FIBROBLASTS FROM CONTROL AND LESCH-NYHAN PATIENTS
S. P. Hussain, J. A. Duley And G. P. Connolly - p377

A CASE OF CLASSICAL XANTHINURIA TYPE 1 DETERMINED BY THE SIMPLIFIED ALLOPURINOL LOADING TEST-NEW MUTATION IN XANTHINE DEHYDROGENASE GENE
K. Ichida, K. Takahashi, H. Matsuda, H. Kimura And T. Hosoya - p379

THE APPLICATION OF HPLC/ESI TANDEM MS ON URINE FOR THE SCREENING OF DISORDERS OF PURINE AND PYRIMIDINE METABOLISM
T. Ito, A. B. P. Van Kuilenburg, A. J. Haasnoot, A. H. Bootsma, A. Van Cruchten, Y. Wada And A. H. Van Gennip - p380

INFLUENCE OF HEAT STRESS ON MYOCARDIAL METABOLISM AND FUNCTIONAL RECOVERY AFTER CARDIOPLEGIC ARREST: A 31P N.M.R. STUDY
J. Jayakumar, R. T Smolenski, M. Amrani And M. H. Yacoub - p381

EFFECTS OF HEAT STRESS ON METABOLISM OF HIGH-ENERGY PHOSPHATES: COMPARISON OF NORMOTHERMIC AND HYPOTHERMIC ISCHEMIA
J. Jayakumar, R. T. Smolenski, M. Amrani And M. H. Yacoub - p382

25 YEARS OF ENZYMATIC DIAGNOSIS OF LESCH-NYHAN SYNDROME IN POLAND
M. M. Jeżewska - p383

HUMAN LIVER AMP-DEAMINASE - REGULATORY PROPERTIES OF THE ENZYME
K. Kaletha, P. Dutka And G. Nagel-Starczynowska - p384

REGULATORY MECHANISMS OF SMOOTH MUSCLE AMP-DEAMINASE
K. Kaletha, G. Szymańska And G. Nagel-Starczynowska - p386

ECTO-5'-NUCLEOTIDASE ACTIVITY IS REDUCED IN THE PRESENCE OF TNF-a IN HUMAN ENDOTHELIAL CELLS
K. K. Kalsi, C. Lawson, A. Mccormack, M. H. Yacoub And R. T. Smolenski - p387

DIFFERENCES IN ADENINE INCORPORATION BETWEEN HUMAN AND RAT HEART ENDOTHELIUM
K. K. Kalsi, M. Zych, E. Slominska, Z. Kochan, M. H. Yacoub And R. T. Smolenski - p388

THE PHOSPHORYLATION OF NUCLEOSIDE ANALOGS BYDEOXYRIBONUCLEOSIDE KINASES
A. Karlsson, C. Zhu And M. Johansson 389

MOLECULAR STUDIES IN ADENYLOSUCCINATE LYASE (ADSL) DEFICIENCY
S. Kmoch, H. Hartmannová, J. Krijt, B. Stiburková, M. Ždánská And I. Šebesta - p390

RECOMBINANT EXPRESSION OF A MULTISUBSTRATE DEOXYNUCLEOSIDE KINASE FROM DROSOPHILA MELANOGASTER
W. Knecht, C. Lenz, L. Sondergaard, J. Piskur And B. Munch-Petersen - p391

EXPRESSION AND PURIFICATION OF MURINE DIHYDROOROTATE DEHYDROGENASE AND ITS INHIBITION BY DICHLOROALLY- LAWSONE, REDOXAL, BREQUINAR AND LEFLUNOMIDE-A771726
W. Knecht, A. Ullrich, M. Löffler, K. K. Kalsi, M. Zych, E. Slominska, Z. Kochan, M. H. Yacoub And R. T. Smolenski - p392

DETERMINATION OF NUCLEOTIDES AND ITS METABOLIC PRODUCTS IN HUMAN SALIVA
B. Kochańska, R. T. Smoleński And N. Knap - p394

ADENOSINE AND HYPOXANTHINE INHIBITS NEURITE OUTGROWTH FROM HUMAN BRAIN CELLS
A. V. Korenevsky, J. A. Duley And G. P. Connolly - p396

CATECHOLAMINE CONTENT OF NEUROBLASTOMA:MODELLING LESCHNYHAN SYNDROME (LNS)
A. V. Korenevsky, J. A. Duley And G. P. Connolly - p398

ELEVATED SUCCINYLPURINES IN THE CEREBROSPINAL FLUID OF PATIENT WITH FUMARASE DEFICIENCY
J. Krijt, J. Zeman, S. Kmoch, L. Stratilová, H. HansÍková And I. ©ebesta - 400

GEMCITABINE INDUCED CELL CYCLE DISTURBANCES AND APOPTOSIS IN LUNG CANCER CELL LINES; BASIS FOR COMBINATION THERAPY WITH TOPOTECAN AND TAXOL
J. R. Kroep, G. Giaccone, C. Tolis, C. G. Ferreira, H. M. Pinedo And G. J. Peters - p401

DEOXYCYTIDINE KINASE AND DEAMINASE ACTIVITIES IN HUMAN LIVER AND LIVER METASTASIS
J. R. Kroep, H. M. Pinedo, D. A. Voorn, W. J. P. Loves, C. L. Van Der Wilt, C. J. Van Groeningen And G. J. Peters - p402

PARTIAL HYPOXANTHINE - GUANINE PHOSPHORIBOSYL - TRANSFERASE DEFICIENCY IN YOUNG MAN
M. Kumšta, J. Krijt And I. Šebesta - p403

CEREBROSPINAL FLUID HIPOXANTHINE, XANTHINE AND URIC ACID CONCENTRATIONS IN DIFFERENT INHERITED METABOLIC DISEASES (IMD)
L. Laróvere, A. Latini, C. E. Coronel And R. D. De Kremer - p404

CHARACTERISTIC CHANGES IN ERYTHROCYTE NUCLEOTIDES IN HAEMOLYTIC ANAEMIA WITH BASOPHILIC STIPPLING OF DIFFERING AETIOLOGY
A. Laurence, J. A. Duley, H. A. Simmonds And M. Layton - p406

YEAST: A EUCARYOTIC MODEL TO STUDY THE GENETIC REGULATION OF PURINE METABOLISM
K. Lecoq And B. Daignan-Fornier - p407

ISOZYMES OF ADENYLOSUCCINATE LYASE IN HUMAN TISSUES
A. Liacini, S. Marie, V. Race, M. F. Vincent And G. Van Den Berghe - p408

DEMONSTRATION OF DIHYDROOROTATE DEHYDROGENASE MANIFESTATION IN HUMAN AND BOVINE SPERMATOZOA
M. Löffler, C. Dietz, E. Hinsch, K. Grein, P. Edelmann And V. Schneider - p409

AMPD1: ANCIENT MUTATIONS PROVIDE INSIGHT INTO THE PATHOGENESIS OF MODERN DAY DISORDERS
E. Loh, P. Oefner And E. Holmes - p411

MORPHOGENESIS OF B103 NEUROBLASTOMA AND B103-4C ITS MUTANT DERIVATIVE: MODELLING LESCH-NYHAN SYNDROME
M. H. Y. Ma., N. C. Stacey, J. A. Duley And G. P. Connolly - p412

CHARACTERISATION OF HYPOXANTHINE-GUANINE PHOSPHORIBOSYL-TRANSFERASE- DEFICIENT (HGPRT-) NEUROBLASTOMA: MODELS FOR LESCH-NYHAN SYNDROME
M. H. Y. Ma, N. C. Stacey, A. V. Korenevsky, J. A. Duley And G. P. Connolly - p414

CHARACTERIZATION OF PROTEIN KINASE C-MEDIATED PHOSPHORYLATION OF HUMAN AMP DEAMINASE 3
D. K. Mahnke-Zizelman And R. L. Sabina - p416

METHANETRISPHOSPHONATE AND ITS ADENINE NUCLEOTIDE DERIVATIVES AS INHIBITORS OF HUMAN AND PLANT DIADENOSINE TETRAPHOSPHATE HYDROLASES
D. Maksel, K. Gayler, X. Liu, M. Blackburn, A. Mclennan And A. Guranowski - p418

A MUTATION IN THE 5' UTR OF THE ADSL GENE IN A PATIENT WITH ADENYLOSUCCINATE LYASE DEFICIENCY
S. Marie, V. Race, M. C. Nassogne, M. F. Vincent And G. Van Den Berghe - p419

PURINE NUCLEOTIDE CATABOLISM IN RAT LIVER LABELLING OF URIC ACID AND ALLANTOIN AFTER ADMINISTRATION OF VARIOUS LABELLED PRECURSORS
E. Marinello, R. Pagani, L. Arezzini, B. Porcelli, G. Cinci And L. Terzuoli - p420

DINUCLEOSIDE POLYPHOSPHATES ' FRIEND OR FOE?
A. G. Mclennan - p421

RELATION BETWEEN FRACTIONAL EXCRETION OF URIC ACID AND FASTING SERUM GLUCOSE IN MALE CHILDREN
E. Messina And A. Giacomello - p422

PYRIDINE NUCLEOTIDES IN ERYTHROCYTES AND LYMPHOCYTES OF HPRT DEFICIENT PATIENTS
V. MICHELI, G. JACOMELLI, S. SESTINI, L. NOTARANTONIO, F. DI MARCELLO, L. Peruzzi And G. Pompucci - p423

NUCLEOTIDE METABOLISM IN AN ITALIAN APRT DEFICIENT PATIENT V. MICHELI, G. JACOMELLI, S. BARBERI, B. BURRONI, F. DI MARCELLO,
L. Notarantonio, L. Peruzzi, S. Mazzaferro And G. Pompucci - p425

THE ROLE OF IMP DEHYDROGENASE IN THE REGULATION OF GUANINE NUCLEOTIDES
B. S. Mitchell, J. Jin Gu, K. Gathy, J. Spychala, R. Flatley And A. P. A. Stegmann - p427

REAL DEFECT OF AMPD1 ACCOMPANIED WITH MYOPATHY: NEW MISSENSE MUTATIONS FOUND IN A JAPANESE PATIENT
T. Morisaki, H. Morisaki, I. Higuchi, M. Osame And M. Abe - p428

LOCALIZAION OF ADENOSINE DEAMINASE (ADA) AND PURINE NUCLEOSIDE PHOSPHORYLASE (PNP) IN HUMAN HEPATIC AND RENAL TISSUES - IMMUNOHISTOCHEMICAL METHOD
Y. Moriwaki, T. Yamamoto, J. Yamakita, S. Takahashi And Z. Tsutsumi - p429

THERAPEUTIC APPLICATION OF MYCOPHENOLIC ACID IN AUTOIMMUNE DISEASES AND TRANSPLANTATION MEDICINE
M. M. Müller, A. Heinschink, A. Griesmacher And I. Neumann - p430

MOLECULAR STUDIES OF 5'NUCLEOTIDASES: PAST ACHIEVEMENTS AND FUTURE POTENTIAL
A. C. Newby - p431

DO SUBJECTS WITH MUTATION IN MUSCLE SPECIFIC AMP DEAMINASE GENE HAVE ANENHANCED BLOOD FLOW RESPONSE TO SPRINT EXERCISE ?
B. Norman, R. L. Sabina And E. Jansson - p432

GENETIC ANALYSIS OF ERYTHROCYTE AMP DEAMINASE DEFICIENCY
N. Ogasawara, Y. Yamada And H. Goto - p433

CYTOSOLIC PURINE 5'-NUCLEOTIDASE FROM CHICKEN HEART: AN ISOZYME OF THE LIVER ENZYME AS EVIDENCED BY NORTHERN BLOT ANALYSIS
J. Oka - p434

ABNORMAL PURINE AND PYRIMIDINE NUCLEOTIDE CONTENT IN PRIMARY ASTROGLIA CULTURES FROM HGPRT- DEFICIENT TRANSGENIC MICE
D. Pelled, O. Sperling And E. Zoref-Shani - p435

SCIENTIFIC BASIS FOR EFFECTIVE COMBINATION CHEMOTHERAPY
G. J. Peters - p436

A COMPETITIVE TEMPLATE RT-PCR TO MEASURE mRNA ENCODING FOR FOLATE METABOLIZING ENZYMES, SUCH AS THYMIDYLATE SYNTHASE, IN LEUKEMIA AND COLON CANCER
G. J. Peters, M. G. Rots, P. Noordhuis, R. Mauritz, J. C. Willey, J. P. Demuth, C. H. Van Zantwijk, R. Pieters And G. Jansen - p437

NUCLEOSIDE 5'-TETRAPHOSPHATE HYDROLASE FROM HUMAN PLACENTA
M. Pietrowska - Borek, M. Szalata And A. Guranowski - p439

DIADENOSINE POLYPHOSPHATE RECEPTORS: FROM RAT AND GUINEA-PIG BRAIN TO HUMAN CENTRAL NERVOUS SYSTEM
J. Pintor, M. Díaz-Hernández, J. Gualix, R. Gómez-Villafuertes And M. T. Miras - p440

DIFFERENT RESPONSES FOR Ap5A AND ATP IN HUMAN CEREBROCORTICAL SYNAPTIC TERMINALS
J. Pintor, M. Díaz-Hernández, J. Gualix, R. Gómez-Villafuertes And M. T. Miras - p441

THE ADENOSINE-INDUCED MECHANISM FOR THE ACQUISITION OF ISCHEMIC TOLERANCE IN PRIMARY RAT NEURONAL CULTURES
A. Reshef, O. Sperling And E. Zoref-Shani - p442

OXYPURINE TRANSPORT IN HUMAN RENAL BRUSH-BORDER MEMBRANE VESICLES (BBMV)
F. Roch-Ramel And B. Guisan - p443

ECTO-5'-NUCLEOTIDASE ACTIVITY AND CD73 EXPRESSION IN PATIENTS AT DIFFERENT STAGES OF THE B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA
F. Rosi, G. Marotta, D. Raspadori, B. Bellisai, E. Marinello, F. Carlucci And A. Tabucchi - p445

ASSOCIATION OF ECTO-5'-NiTCLEOTIDASE ACTIVITY AND erbB-2 RECEPTOR FUNCTION
F. Rosi, A. Tabucchi, F. Carlucci, E. Marinello, G. Cinci And L. Zanoni - p447

HUMAN DIADENOSINE TRIPHOSPHATE HYDROLASE: PRELIMINARY CHARACTERIZATION AND COMPARISON WITH THE HUMAN TUMOR SUPPRESSOR FHIT PROTEIN
P. Rotllán, A. C. Asensio And S. Oaknin - p449

THE EXPERIMENTAL AND THEORETICAL STUDY OF 6-THIOGUANINE AND THEIR DERIVATIVES
Y. Rubin And J. Leszczynski - p450

LEFLUNOMIDE AND METHOTREXATE INHIBIT T-LYMPHOCYTE PROLIFERATION BY DIFFERENT MOLECULAR MECHANISMS INVOLVING PURINE AND PYRIMIDINE DE NOVO SYNTHESIS
K. Rückemann, L. D. Fairbanks And H. A. Simmonds - p451

TOWARDS AN UNDERSTANDING OF THE FUNCTIONAL SIGNIFICANCE FOR N-TERMINAL DOMAIN DIVERGENCE IN HUMAN AMP DEAMINASE ISOFORMS
R. L. Sabina And D. K. Mahnke-Zizelman - p453

PURINE COMPONENTS OF URINARY CALCULI
K. Safranow And Z. Machoy - p455

DIMINISHED EXPRESSION OF ADENOSINE KINASE IN DIABETIC RATS
- p456

COMPARISON OF RECOMBINANT AMP AND IMP/GMP CYTOSOLIC 5'NUCLEOTIDASES (CN-I AND CN-II) IN ADENOSINE FORMATION DURING ATP DEGRADATION IN COS-7 CELLS
G. B. Sala-Newby, N. Freeman, A.C. Newby And A. C. Składanowski - p457

SUCCINYLPURINEMIC AUTISM: POSSIBLE SIDE EFFECTS OF D-RIBOSE THERAPY
C. Salerno, M. Celli, R. Finocchiaro, M. Matrunola, P. D'Eufemia And O. Giardini - p458

CAPILLARY ELECTROPHORESIS AS A TOOL FOR DETERMINING THE LEVEL OF OROTIC ACID AND URACIL IN PATIENTS WITH UREA CYCLE DEFECTS
C. Salerno, P. D'Eufemia, M. Celli, R. Finocchiaro, C. Crifo And O. Giardini - p459

DEFECTIVE ADENYLOSUCCINATE LYASE IS INHIBITED BY THE LIPID PEROXIDATION PRODUCT 4-HYDROXY-2-NONENAL
C. Salerno, W. G. Siems And C. Crifó - p460

EFFECTS OF HEAT STRESS ON MITOCHONDRIAL ADENINE NUCLEOTIDE POOLS IN RAT MYOCARDIUM
I. A. Sammut, J. Jayakumar, M. H. Yacoub And R. T. Smolenski - p461

MODULATION OF HUMAN DEOXYCITIDINE KINASE ACTIVITY AS A RESPONSE TO DIFFERENT CELLULAR STRESSES
M. Sasvári-Székely, Z. Csapó, T. Spasokukockaja, I. Talianidis And M. Staub - p462

HIGH REACTIVITY OF ANTI-HIV NUCLEOTIDE D4T WITH NUCLEOSIDE DIPHOSPHATE KINASE AT THE MOLECULAR LEVEL
B. Schneider, R. Biondi, R. Sarfati, C. Guerreiro, D. Deville-Bonne And M. Veron - p463

CONTROL OF ENERGY METABOLISM IN THE HEART AND ENDOTHELIAL CELLS
J. Schrader, U. K.M. Decking, T. Stumpe And O. Culic - p465

CYCLIC NUCLEOTIDE ANALOGS AS PROSPECTIVE DRUGS
F. Schwede, H.-G.Genieser And B. Jastorff - p466

INDICATIONS FOR INVESTIGATIONS OF PURINE AND PYRIMIDINE DISORDERS
I. Sebesta, J. Krijt, S. Kmoch, M. Kumsta And B. Stiburkova - p467

PYRIDINE NUCLEOTIDE CONCENTRATION AND ACTIVITY OF RELATED ENZYMES IN HUMAN LYMPHOCYTES
S. Sestini, G. Jacomelli, M. Pescaglini, V. Micheli And G. Pompucci - p468

THIOPURINE METHYL TRANSFERASE ACTIVITY IS CORRELATED TO AZATHIOPRINE TOXICITY IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE
E.-M. Shobowale-Bakre, J. Duley, C. Hassan, A. Ansari, D. Reffitt, J. Meenan And J. D. Sanderson - p469

SEVERAL LIGASES AND FIREFLY LUCIFERASE CATALYZE THE SYNTHESIS OF DINUCLEOSIDE POLYPHOSPHATES
A. Sillero And M. A. Günther Sillero - p471

ROLE OF 5'-NUCLEOTIDASES (c-N-II AND e-N-s) AND AMP DEAMINASE IN THE METABOLISM OF AMP IN THE CYTOSOL OF RAT BRAIN. AN EXPERIMENTAL AND THEORETICAL APPROACH
A. Sillero, A. Torrecilla, A. F. P. Marques, N. A. Teixeira, E. A. Atencia And M. A. Günther Sillero - p472

DEMONSTRATION IN LIVING HUMAN CELLS THAT CARBAMOYL ASPARTATE AND CARBAMOYL PHOSPHATE ACCUMULATE WHEN DIHYDROOROTATE DEHYDROGENASE IS INHIBITED
H. A. Simmonds, K. Ruckemann, L. Fairbanks And E. A. Carrey - p473

ENHANCED ADENOSINE PRODUCTION IN HUMAN ENDOTHELIUM BY INHIBITION OF ADENOSINE METABOLISM AND NUCLEOTIDE PRECURSOR SUPPLY
R. T. Smolenski, K. K. Kalsi, C. C.Gray, M. Zych, Z. Kochan And M. H. Yacoub - p474

MOLECULAR CHARACTERIZATION OF RENAL ION TRANSPORT SYSTEMS - CLONING OF A PUTATIVE URATE TRANSPORTER / CHANNEL FROM CULTURED LLC- PK1 KIDNEY EPITHELIAL CELLS AND HUMAN KIDNEY
F. Spitzenberger, J. Gräßler And H.-E. Schröder - p475

CELL-SPECIFIC REGULATION OF ECTO-5'-NUCLEOTIDASE PROMOTER: THE ROLE OF BETA-CATENIN, APC AND SMAD SIGNALING MOLECULES
J. Spychala - p477

ENHANCED ADHESION OF NEUROBLASTOMA MODELS OF LESCH-NYHAN SYNDROME (LNS) AND HUMAN SKIN FIBROBLAST FROM LNS PATIENTS
N. Ch. Stacey, M. H.Y. Ma, J. A. Duley And G.P. Connolly - p478

MORPHOLOGICAL ABNORMALITIES OF HGPRT-DEFICIENT MOUSE N2a NEUROBLASTOMA: IMPLICATIONS FOR NEURONAL DEVELOPMENT IN LESCH NYHAN SYNDROME
N. Ch. Stacey, M. H. Y. Ma, J. A. Duley And G. P. Connolly - p480

CHANGES IN MEMBRANE PHOSPHOLIPID BIOSYNTHESIS INDUCED BY CHLOROPROMASINE AND NUCLEOSIDE ANALOGUES: ITS THERAPEUTIC CONSEQUENCES
M. Staub, R. Sümeg, M. Sasvári-Székely And A. Simmonds - p482

FAMILIAL JUVENILE HYPERURICAEMIC NEPHROPATHY (FJHN) IN THREE CZECH FAMILIES
A. Stibůrková, E. Pospíšilová, T. Paterová, J. Krijt, M. Kumšta, I. Šebesta And S. Kmoch - p484

REDUCED PURINE 5'-NUCLEOTIDASE ACTIVITY IN LYMPHOCYTES OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
J. Stolk, A. Boerbooms, R. De Abreu, D. De Koning And L. Van De Putte - p485

THE EFFECT OF DIFFERENT NUCLEOSIDE-5'-THIOSULPHATES ON THE SALVAGE OF DEOXYPYRIMIDINE NUCLEOSIDES IN HUMAN LYMPHOCYTES
K. Szikla, Z. Kazimierczuk, S. Virga And M. Staub - p487

ADENYLOSUCCINATE LYASE IN HUMAN BLOOD LYMPHOCYTES
A. Tabucchi, F. Carlucci, F. Rosi, R. Guerranti, G. Marotta And E. Marinello - p488

INCREASED VISCERAL FAT ACCUMULATION IN PATIENTS WITH GOUT -A DETRIMENTAL FACTOR FOR ATHEROSCLEROSIS IN GOUT
S. Takahashi, T. Yamamoto, Z. Tsutsumi, Y. Moriwaki, J.-I. Yamakita And K. Higashino - p489

HPLC-ANALYSIS OF LOW AMOUNTS OF METHOTREXATE AND ITS POLYGLUTAMATES IN RED BLOOD CELL LYSATES AFTER LOW-DOSE METHOTREXATE MAINTENANCE TREATMENT FOR CHILDHOOD ACUTE LYMPHOBLASTIC LEUKAEMIA
P. G. J. H. Ter Riet, C. Brouwer, R. A. De Abreu, J. P. M. Bökkerink And F. J. M. Trijbels - p490

ISOLATION AND CHARACTERIZATION OF AMP-SELECTIVE 5'-NUCLEOTIDASE FROM CYTOSOL OF PIGEON BREAST MUSCLE AND BRAIN
K. Tkacz, A. C. Składanowski And W. Makarewicz - p491

ENZYME ACTIVITIES OF PURINE METABOLISM IN NEUROLOGICAL DISORDERS
M .G. Tozzi, R. Pesi, M. Camici, G. Jacomelli, L. Peruzzi And V. Micheli - p492

COMBINATION THERAPY IN CHILDHOOD LEUKEMIA. IN VITRO STUDIES OF THIOPURINES AND INHIBITORS OF PURINE METABOLISMS ON APOPTOSIS
R. Trueworthy, R. De Abreu, T. Vogels-Mentink And L. Lambooy - p494

ACCELERATED OXIDATION OF SERUM LOW DENSITY LIPOPROTEIN IN GOUT AND ITS IMPROVEMENT BY ALLOPURINOL
Z. Tsutsumi, T. Yamamoto, S. Takahashi, Y. Moriwaki, J.-I. Yamakita, K. Matsui And K. Higashino - p495

LYMPHOCYTE PHENOTYPING OF RENAL TRANSPLANTED PATIENTS UNDER TWO DIFFERENT IMMUNOSUPPRESSIVE PROTOCOLS
B. Tzanno-Martins, P. AraÚjo, N. Orii, A. J. S. Duarte, F. J. Paula, J. A. Duley, W. Nahas, S. Arap, E. Ianhez And P. R. Chocair - p496

DEOXYCYTIDINE KINASE TRANSFECTION AND UPREGULATION OF THYMIDINE KINASE 2 INCREASED SENSITIVITY TO CYTIDINE ANALOGUES IN RESISTANT CELLS
C. Van Der Wilt, W. Loves, J. Padron, I. Talianidis, S. Eriksson And G. J. Peters - p498

PITFALLS IN THE DIAGNOSIS OF PATIENTS WITH A DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY IN BLOOD CELLS
A. B. P. Van Kuilenburg, H. Van Lenthe And A. H. Van Gennip - p499

THE ACTIVITY OF DIHYDROPYRIMIDINE DEHYDROGENASE AND mRNA EXPRESSION IN HUMAN BLOOD CELLS
A. B. P. Van Kuilenburg, P. Vreken, H. Van Lenthe, R. Meinsma And A. H. Van Gennip - p500

GEMCITABINE AFFECTS THE DETECTION OF DEOXYRIBO-NUCLEOTIDES WITH A DNA POLYMERASE ELONGATION ASSAY
C. J. A. Van Moorsel, K. Smid, H. M. Pinedo And G. J. Peters - p501

CYCLOPENTENYL CYTOSINE INHIBITS CTP SYNTHETASE IN PEDIATRIC ACUTE NON-LYMPHOCYTIC LEUKEMIA
A. C. Verschuur, A. H. Van Gennip, R. Leen, P. A. Voute - p502

And A. B. P. Van Kuilenburg RESCUE OF SYMPATHETIC NEURONS FROM NGF-WITHDRAWAL APOPTOSIS BY ADENOSINE
A. R. Wakade, T. D. Wakade And D. A. Przywara - p503

IN VITRO CYTOTOXICITY OF THE TRICYCLIC ANALOGUES OF ACYCLOVIR
M. Wołuń, M. Ciesielski, T. Gośliński, J. B. Warchoł And B. Golankiewicz - p504

IS THERE A RESCUE - SCHEME FOR THE CHEMOTHERAPY WITH GEMCITABINE?
F. Wosegien And T. Graeve - p505

TOPOLOGICAL DELIMITATION OF REDOX ACTIVE CYSTEINE IN PIG HEART AMP-DEAMINASE
M. Woźniak, J. Purzycka-Preis, D. Budźko, E. Kossowska, D. Kulawiak-Gałąska And Z. Wypych - p506

HYPOXANTHINE GUANINE PHOSPHORIBOSYLTRANSFERASE (HPRT) DEFICIENCY IN JAPANESE AND KOREAN
Y. Yamada, H. Goto, N. Nomura, H. Kitoh And N. Ogasawara - p507

EFFECT OF AMINO ACIDS ON THE PLASMA CONCENTRATIONS AND URINARY EXCRETION OF URIC ACID AND URIDINE
T. Yamamoto, Y. Moriwaki, S. Takahashi, Z. Tsutsumi, J.-I. Yamakita And K. Higashino - p508

STRUCTURE AND FUNCTION OF ECTO-NUCLEOTIDASES AND THEIR ROLE IN THE ISCHEMIC BRAIN
H. Zimmermann, N. Braun, P. Heine, B. Kegel And K. Kohring - p509

KELLEY-SEEGMILLER SYNDROME DUE TO A UNIQUE VARIANT OF HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE: REDUCED AFFINITY FOR 5-PHOSPHORIBOSYL-1-PYROPHOSPHATE MANIFESTED ONLY AT LOW, PHYSIOLOGICAL SUBSTRATE CONCENTRATIONS
E. Zoref-Shani, S. Feinstein, Y. Frishberg, Y. Bromberg And O. Sperling - p510

TRANSFORMATION OF DIMERIC LOW-AFFINITY FORM OF HUMAN THYMIDINE KINASE (TK1) TO THE TETRAMERIC HIGH-AFFINITY FORM (ATP-FORM)
J. Żuberek, B. Munch-Petersen, D. Shugar And B. Kierdaszuk - p511
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